冠心病患者血清幽门螺旋杆菌特异性抗体及其细胞毒素相关蛋白特异性抗体检测及意义

摘要

Objective To analyze and probe into the Detection and significance of Serum Helicobacter pylori specific anti-body and its related protein specific antibodies in patients with coronary heart disease.Methods 80 patients were showed coronary artery disease by coronary angiography and who accepted treatments in our hospital from November,2013 to October,2015 were se-lected as theas experimental group,while 80 normal subjects were performed by the coronary angiography during the same period were selected as the control group.Then,the serum antibody was determined by ELISA assay.Results The serum HPLgC,anti HPLgM and anti CagA-HPLgC antibody positive detection rate of patients in the experimental group were significantly higher than the control group,the difference was statistically significant between the two groups(P<0.05).Conclusion In patients with coronary heart disease,the detection of serum Helicobacter pylori specific antibodies and its cytotoxic associated protein specific antibodies which can effectively prevent the incidence of coronary heart disease,thereby reducing the risk factors of coronary heart disease.%目的：分析探讨冠心病患者血清幽门螺旋杆菌特异性抗体及其细胞毒素相关蛋白特异性抗体检测及意义。方法冠心病80例患者为实验组，选同期进行冠脉造影显示正常的80例为对照组。使用ELISA实验法进行血清抗体的测定。结果实验组患者的血清HPLgC、抗HPLgM及抗CagA-HPLgC抗体阳性检出率明显高于对照组患者，两组之间比较，差异有统计学意义（P<0.05）。结论冠心病患者血清幽门螺杆菌特异性抗体及其细胞毒素相关蛋白特异性抗体检测，可以有效预防冠心病的发生率，从而减少冠心病的危险因素。