Objective To investigate the clinical value of intact parathyroid hormone (iPTH) combined with calcium and phosphorus detection in patients with chronic kidney disease (CKD). Methods A total of 92 CKD pa-tients of stage 3-5 in Department of Nephrology in our hospital from January 2015 to June 2016 were enrolled in the study, among which 52 of stage 3-4 were included into the early chronic renal failure (CRF) group and 40 of stage 5 were included into end stage renal disease (ESRD) group. During the same period, 40 healthy subjects were included in-to the control group. Serum calcium and phosphorus and iPTH levels were detected and compared among the three groups. Results There were no statistically significant difference between early CRF group and the control group in calcium, phosphorus levels (P>0.05), but the serum iPTH in early CRF group was significantly higher than that in the control group, (105.54 ± 31.45) pg/mL vs (30.23 ± 11.62) pg/mL (P<0.05). Serum calcium in ESRD group was (2.02 ± 0.24) mmol/L, significantly lower than (2.23 ± 0.48) mmol/L in early CRF group and (2.34 ± 0.32) mmol/L in the control group. Phosphorus and iPTH levels in ESRD group were (1.91±0.77) mmol/L and (413.53±114.75) pg/mL, significantly higher than (1.34±0.46) mmol/L, (105.54±31.45) pg/mL in ESRD group and (1.17±0.43) mmol/L, (30.23±11.62) pg/mL in the control group, P<0.05. Conclusion Serum iPTH determination can be used to reflect the progress degree of renal function in patients with CKD, and its combination with calcium and phosphorus is of further guidance in the early diag-nosis and treatment of CKD.%目的 探讨全段甲状旁腺激素(iPTH)联合钙磷测定在慢性肾脏病(CKD)患者中的应用价值.方法 选择2015年1月至2016年6月期间我院肾内科收治的CKD3~5期患者92例为研究对象,将52例CKD3~4期患者纳入慢性肾功能衰竭(CRF)早期组,40例CKD5期患者纳入终末期肾病组,并选择40例健康体检者纳入对照组,检测并比较三组受检者的血清钙磷及iPTH水平.结果 CRF早期组与对照组比较,血钙、血磷水平差异均无统计学意义(P>0.05),但CRF早期组患者血清iPTH为(105.54±31.45)pg/mL,明显高于对照组的(30.23±11.62)pg/mL,差异有统计学意义(P<0.05);终末期肾病组患者血钙为(2.02±0.24)mmol/L,明显低于CRF早期组的(2.23±0.48)mmol/L及对照组的(2.34±0.32)mmol/L,血磷及iPTH水平分别为(1.91±0.77)mmol/L、(413.53±114.75)pg/mL,均明显高于CRF早期组[(1.34±0.46)mmol/L、(105.54±31.45)pg/mL]及对照组[(1.17±0.43)mmol/L、(30.23±11.62)pg/mL],差异均有统计学意义(P<0.05).结论 血清iPTH测定可用于反映CKD患者的肾功能进展程度,进一步联合钙磷测定对CKD的早期诊断和治疗具有的指导意义.
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