果葡糖浆诱导实验性代谢综合征大鼠模型

摘要

To investigate the metabolic syndrome (MS) induced by excessive consumption of high-fructose corn syrups (HFCS). SD male rats were fed with different concentrations of fructose syrup water for 16 weeks. The effect of the HFCS on MS may be showed by the measurement of body weight, blood pressure, blood lipids and other indexes. Compared with normal group, the body weight, systolic blood pressure (SBP), fasting plasma glucose (FPG), blood lipid, fasting insulin(FINS)were higher in model groups, while the insulin sensitivity was decreased. Especially, the effect caused by 15%and 20%of fructose syrup water (solid content 7.2%and 14.8 %) was more obvious. The metabolic syndrome could be induced by excessive consumption of HFCS in a long period.%研究过量饮用果葡糖浆导致的代谢综合征。使用不同浓度的果葡糖浆水饲养雄性SD大鼠16周，通过体重、血压、血糖和血脂等指标的测定考察其对代谢综合征的影响。各模型组，尤其是模型2组和模型3组大鼠较正常组出现了体重、血压、血脂、空腹血糖、胰岛素水平增高，胰岛素敏感下降的现象。15%和20%的果葡糖浆水（可溶固形物含量分别为7.2%和14.8%）造成的代谢综合征效果更明显。长时间大量饮用果葡糖浆会导致代谢综合征的产生。