Amphiphilic polysaccharides is a class of semisynthetic polymer with low toxicity,good biocompatibility and degradable.It can form self-assembled hydrophobic-hydrophilic core-shell structure in aqueous.Recently,this kind of micelles got more attention in the field of food science,medicine,biomedical engineering and even material science.The polysaccharide-based micelles research is mainly focused on improving the bioactivity of hydrophobic compounds.Based on the literatures review of the last five years,this paper reviews the applications of amphiphilic polysaccharide-based micelles on targeted delivery,scattered solubilization,delayed release,as well as bioavailability of hydrophobic substances.Finally,the existing problems and future development in this field are also discussed.%两亲性多糖往往是亲水性多糖适度疏水化改性而获得的一类低毒、生物相容性和可降解性良好的半合成聚合物,其在水相中能自发聚集组装成为具有疏水核-亲水壳结构的胶束.最近,这类胶束受到食品科学、药学、生物医学工程乃至材料学相关科学家的广泛重视,其研究急剧升温,且主要集中在利用其改善疏水性物质生物活性方面.论文主要以近5年文献为基础,全面综述了两亲性多糖基胶束在疏水物质分散增溶、靶向递送、廷缓释放、生物利用度提升及稳定性增强等方面的应用,并在此基础上对该领域存在的问题及今后的发展方向进行了探讨.
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