CT导向下125I放射性粒子植入治疗腹膜后淋巴结转移的疗效

摘要

Objective To study the clinical value and efifcacy of CT guided interstitial implantation of radioactive 125 I seeds for the therapy of retroperitoneal lymph node metastases. Methods 25 cases with retroperitoneal lymph node metastases were treated with CT guided interstitial implantation of radioactive 125 I seeds by TPS. Post operative CT review scans were performed immediately after implantation. The effect was followed-up by CT scans repeated every month post operation. The change of pain was recorded. Results The seeds of 25 cases were distributed successfully in the retroperitoneal lymph node metastases. The total effect rates in short period were 64%(16/25), CR 20%(5/25), PR 44%(11/25), NC 20%(5/25), PD 16%(4/25). The easement of pain was obviously. Conclusion It is safe and effective that CT guided interstitial implantation of radioactive 125 I seeds for the therapy of retroperitoneal lymph node metastases . This method can effectively control the growth of tumor, reduce abdominal pain, improve the quality of life of patients, is worthy of clinical application.%目的探讨CT引导下125 I放射性粒子植入术治疗腹膜后淋巴结转移的临床应用及效果。方法对25例腹膜后淋巴结转移患者行CT引导下125 I放射性粒子植入术，先利用TPS系统制订治疗计划，然后在CT引导下行125 I放射性粒子植入，植入后CT扫描观察粒子分布情况，之后每月CT复查，观察病灶大小变化，并记录患者疼痛情况变化，分析治疗效果。结果25例中5例肿瘤完全缓解，11例肿瘤局部部分缓解，5例病灶无变化，4例因局部进展并其他部位转移死亡，局部控制率为64％。疼痛缓解明显。结论 CT引导下125 I放射性粒子植入术治疗腹膜后淋巴结转移安全、有效，可以有效控制肿瘤生长，减轻腹部疼痛，改善患者生活质量，值得临床推广应用。