β-七叶皂苷钠联合甘露醇治疗颅脑损伤后蛛网膜下隙出血

摘要

Objective To study the clinical efifcacy ofβ-aescine sodium combined with mannitol in the treatment of subarachnoid hemorrhage after brain injury.Methods One hundred patients with severe brain injury admitted to the hospital from January 2009 to June 2012 were randomly divided into observation group (50 cases) and control group (50 cases) . The control group was routinely given 20%mannitol and anti-infection treatment. While the observation group was givenβ-aescine sodium ,and the intracranial pressure and complication was observed. Results The intracranial pressure and complication was significantly decreased in the observation group compared with control group(P<0.05).Conclusionβ-aescine sodium combined with mannitol can signiifcant reduce the intracranial pressure and complication.%　　目的分析β-七叶皂苷钠联合甘露醇治疗颅脑损伤后蛛网膜下隙出血的效果。方法将东莞市人民医院2009年1月-2012年6月神经外科收治的颅脑损伤后蛛网膜下隙出血患者100例，随机分为观察组和对照组，各50例。对照组给予抗生素及20%的甘露醇250 mL静脉滴注，4次/d，持续7 d后减量，14 d停药，观察组在此基础上给予给予20 mg β-七叶皂苷钠加入5％葡萄糖250 mL，每日1次，静脉滴注，疗程14 d。比较治疗前后两组患者的颅内压情况及并发症的发生情况。结果与对照组比较，观察组颅内压的降低效果更明显(P<0.05，有统计学意义)，治疗后再出血、血管痉挛和脑水肿的发生率明显降低(P<0.05，有统计学意义)。结论用β-七叶皂苷钠联合甘露醇治疗蛛网膜下隙出血的颅脑损伤患者能起到降低颅内压及减少并发症的作用。