儿童脓毒症相关性脑病发生的危险因素分析

摘要

Objective Investigating on the risk factors of sepsis sepsis associated encephalopathy in children.Methods Collecting the clinical data of 104 cases of children with sepsis, adopting single factor analysis and multi-factor logistic regression analysis to study on the risk factors influencing the occurrence of sepsis associated encephalopathy in children.Results The mortality rate of children with sepsis associated encephalopathy was obviously higher than children with sepsis but no encephalopathy; the proportion of children suffering from sepsis associated encephalopathy with coagulation disorders was higher than children with no coagulation disorders; the proportion of children suffering SAE in cases whose Pediatric Clinical Illness Score (PCIS grade)≤80 grade was highter than thatof above 80 grade group; The difference of urea nitrogen (BUN) and capillary refill time (CRT) in SAE group and no SAE group had statistical significance, and the BUN and CRT in group with sepsis associated encephalopathy was obviously higher than that with no sepsis associated encephalopathy.Conclusion Coagulation disorders and PCIS≤80 grade may be the risk factors to occurrence of sepsis associated encephalopathy.%探讨脓毒症患儿并发脓毒症相关性脑病（sepsis associated encephalopathy,SAE）的危险因素。方法收集珠海市妇幼保健院104例脓毒症患儿的临床资料，采用单因素分析和多因素Logisitic回归分析儿童脓毒症相关性脑病发生的危险因素。结果合并脑病的脓毒症患儿病死率显著高于无合并脑病的脓毒症患儿；有凝血功能障碍患SAE的比例高于没有凝血功能障碍的患儿；小儿危重病例评分（PCIS评分）≤80分的患SAE比例高于＞80分组；尿素氮(BUN)、皮肤毛细血管再充盈时间（CRT）在SAE组与无SAE组的之间的差异有统计学意义（P<0.05），SAE组显著高于无SAE组。结论凝血功能障碍及PCIS≤80分对脓毒症相关性脑病的发生有影响作用。