ObjectiveTo assess the clinical effect of psychological nursing in patients undergoing chemotherapy with small cell lung cancer. Methods180 cases of patients with small cell lung cancer were selected as experimental objects, and randomized assigned into experimental group and control group. Patients in control group received chemotherapy and routine nursing care, and in experimental group received chemotherapy and psychological nursing. The self-rating anxiety scale(SAS) scores, self-rating depression scale(SDS) scores, effect and toxicity of chemotherapy were observed and compared to assess the clinical effect of psychological nursing.Results All patients ifnished with the trial. Before treatment, the SAS score in both group showed no statistical different[ (59.41±4.83) vs (58.95±5.04) ]. After treatment, the SAS score in experiment group were signiifcant reduced than in control group[ (41.40±3.41) vs (63.87±4.48) ] (P<0.01). The SAS score reduced in experiment group [ (59.41±4.83) vs (41.40±3.41) ] (P<0.01), but increased in control group[ (58.95±5.04) vs (63.87±4.48) ](P<0.01). Before treatment, the SDS score in both group showed no statistical different [ (58.50±4.81) vs (59.24±4.75) ]. After treatment, the SAS score in experiment group were signiifcant reduced than in control group [(44.67±4.02) vs (65.23±4.08) ](P<0.01). The SAS score reduced in experiment group [ (58.50±4.81) vs (44.67±4.02) ] (P<0.01), but increased in control group [(59.24±4.75) vs (65.23±4.08) ] (P<0.01).The clinical effect of psychological nursing signiifcantly improved than in control group. ConclusionPsychological nursing can reduce the anxiety and depression in patients with clinical effect of psychological nursing who undergoing chemotherapy, and improve the clinical effect of chemotherapy, reduce the toxicity of chemotherapy, which is worthy to be popularized in clinical practice.%目的：观察心理护理干预对小细胞肺癌患者化疗疗效的影响，总结心理护理经验。方法选取180例小细胞肺癌患者作为研究对象，并随机分为2组,各90例。对照组患者采用足叶乙苷加顺铂方案化疗联合常规护理进行治疗，观察组患者在对照组的基础上加用心理护理干预进行治疗。观察比较2组患者焦虑、抑郁量表评分情况，化疗疗效情况和急性毒性反应情况以评价心理护理的疗效。结果观察组和对照组患者均顺利完成研究，治疗前2组患者SAS评分差异无统计学意义[59.41±4.83）分vs（58.95±5.04）分]，治疗后观察组患者SAS评分明显低于对照组[（41.40±3.41）分vs（63.87±4.48）分]（P＜0.01），观察组患者治疗后SAS评分较治疗前明显降低[（59.41±4.83）分vs（41.40±3.41）分]（P＜0.01），对照组患者治疗后SAS评分较治疗前明显升高[（58.95±5.04）分vs（63.87±4.48）分]（P＜0.01）；治疗前2组患者SDS评分差异无统计学意义[（58.50±4.81）分vs （59.24±4.75）分]，治疗后观察组患者SDS评分明显低于对照组[（44.67±4.02）分vs（65.23±4.08）分]（P＜0.01），观察组患者治疗后SDS评分较治疗前明显降低[（58.50±4.81）分vs（44.67±4.02）分]（P＜0.01），对照组患者治疗后SDS评分较治疗前明显升高[（59.24±4.75)分vs（65.23±4.08）分]（P＜0.01）；观察组患者化疗后评分较化疗前明显降低，差异有统计学意义（P＜0.01）；观察组患者化疗疗效明显优于对照组，差异有统计学意义（z=2.10，P=0.04）；观察组患者化疗急性毒性反应情况明显轻于对照组，其差异有统计学意义（z=2.19，P=0.04）。结论心理护理可以显著改善小细胞肺癌化疗患者的焦虑、抑郁情绪，提高患者化疗疗效，降低化疗毒性反应情况，值得在临床推广应用。
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