Randomized, Double Blind, Placebo controlled Trial of Neuroprotective Effects of Epoetin Alfa in Patients Receiving Adjuvant Chemotherapy for Breast Cancer

摘要

Adjuvant treatment with Adriamycin and cyclophosphamide (AC) clearly prolongs the overall survival in women with breast cancer. Cognitive deficits (e.g. problems with memory and concentration) are common during and after adjuvant breast cancer chemotherapy, but the pathophysiology of cognitive phenomena is unknown. The goal of this project is to study the pathophysiology of cognitive dysfunction in patients receiving adjuvant treatment using Positron Emission Tomography (PET) scan. This study opened to accrual in April 2003. Three patients have been enrolled.