Objective To summarize clinical features and experiences of diagnosis and treatment of isolated gastrodu-odenal Crohn disease( CD). Methods Clinical data of 2 isolated gastroduodenal CD patients was retrospectively analyzed. Results The 2 isolated gastroduodenal CD patients were all young male,and the main symptom was gastric outlet obstruc-tion. One patient had accompanied with belly ache and haematemesis,and underwent appendicectomy at 3rd d after onset,and was confirmed gastroduodenal CD on 9 th d after surgery. Another patient had accompanied with weight loss,mild anemia and hypoalbuminemia,and treatment for peptic ulcer was noneffective,and was confirmed gastroduodenal CD in more than 2 months after onset. Gastroscopes examination for the 2 patients showed that hyperemia,edema and multiple ulcers in the stom-ach and/or duodenum mucous membrane,and cobble-like hyperplasia in duodenum mucous membrane. The histopathological examination showed granulation tissues,fissuring ulcers and small abscesses in mucosa and submucosa. Digestive tract radio-graphy and colonoscopy examination showed that there was no ileocolon lesion. Pulse glucocorticoids therapy was performed for the 2 patients after confirming isolated gastroduodenal CD. Symptoms were relieved quickly,and gastroscopy examination showed the lesions had remarkable alleviated in a short time. Conclusion Clinical manifestations of isolated gastroduodenal CD include gastric outlet obstruction,and accompanied with bleeding and malnutrition sometimes,and therefore differential diagnosis with peptic ulcer should be made.%目的：总结孤立性胃十二指肠克罗恩病（ Crohnˊs disease，CD）的临床特征及诊治经验。方法回顾性分析我院收治的2例孤立性胃十二指肠 CD临床资料。结果2例孤立性胃十二指肠 CD 患者均为男性青年，表现为胃流出道梗阻症状，例1伴腹痛及呕血，起病3 d后行阑尾切除术，术后7 d确诊胃十二指肠CD；例2伴体重下降及轻度贫血、低蛋白血症，按消化性溃疡治疗无效，起病2月余才确诊十二指肠 CD。2例胃镜表现为胃和（或）十二指肠黏膜充血水肿及多发溃疡，十二指肠黏膜铺路石样增生隆起，病理组织学检查见大片增生肉芽组织和裂隙状溃疡、小脓肿形成等，消化道造影及肠镜未提示回结肠病变。确诊后给予糖皮质激素冲击治疗，患者症状迅速缓解，短期内复查胃镜示病变明显减轻。结论孤立性胃十二指肠 CD多表现为胃流出道梗阻症状，可伴出血、营养不良，应注意和消化性溃疡鉴别，糖皮质激素治疗起效快，疗效确切。
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