中日友好医院门诊高风险用药人群识别与分析

摘要

目的：通过对目标时间内药物不良反应（adverse drug reactions，ADR）人群的分析，识别高风险用药人群，并给予相应指导。方法：将中日友好医院2009年1月至2014年1月门诊患者发生ADR进行数据收集并整理分析，通过风险矩阵与Borda序值法相结合，分辨特征人群风险概率和风险程度。结果：男性发生ADR风险略高于女性；部分人群发生ADR时与抗菌药物联用存在相关性；特殊群体用药存高风险且合并其他影响因素。结论：正确识别临床用药高风险人群，对日常药品安全管理具有重要意义，根据患者情况给予适当用药咨询，可减少ADR发生，并改善患者预后。%Objective:By analysis on adverse drug reactions (ADR) of population within the target time, to identify people with high-risk of medication and to provide them with appropriate medication guides.Methods: ADR data from January 2009 to January 2014 in China-Japan Friendship Hospital outpatient were collected and analyzed using risk matrix method combined with Borda order value method. Risk probabilities and the level of risk in characteristic population were distinguished.Results: ADR risk for males was slightly higher than that for females. ADR occurs were correlated to combined use of antibiotic drugs in part of the population. There were high risks of medication in special group of population with other inlfuencing factors.Conclusion:Correctly identifying population with high-risk of clinical medication was important for the daily management of drug safety. Providing with appropriate medication counseling based on the patient's condition could reduce the occurrence of ADR and improve the prognosis of patients.