2型糖尿病患者葡萄糖耐量试验后胰高糖素样肽1水平变化

摘要

Objective To investigate the relationship of glucagon-like peptide 1 (GLP-1 )level with blood glucose,β-cell function,insulin resistance after glucose tolerance test(OGTT,oral glucose,75 g)in type 2 diabetes mellitus(T2DM)patients.Methods Thirty-five T2DM patients and 30 healthy subjects(control group)who had fasted for 12 hours underwent OGTT,then,0,0.5,2 hours of blood sample were collected,the plasma glucose,insulin,GLP-1,glycosylated hemoglobin(HbA1 c)were measured.Results 0 hour,0.5 hour,2 hour glucose and 0 hour insulin, HbA1 c levels of T2DM group were significantly higher compared with those of healthy control group(P 0.05 ).Conclusion Postprandial GLP-1 rise relates with meal stimulation GLP-1 level may relate with blood glucose,islet function and insulin resistance.%目的：探讨2型糖尿病(T2DM)患者葡萄糖耐量试验(OGTT,口服葡萄糖75 g)后胰高糖素样肽1(GLP-1)水平与血糖、胰岛β细胞功能、胰岛素抵抗的关系。方法 T2DM 患者35例及健康对照组30例均禁食12小时以上后行 OGTT,采集0(即空腹)、0.5、2小时血样,分别测定血浆葡萄糖、胰岛素、GLP-1浓度、糖化血红蛋白(HbA1 c)水平。结果 T2DM 患者的0、0.5、2小时血糖、空腹胰岛素及 HbA1 c 明显高于对照组(P 0.05)。结论餐后 GLP-1水平的上升与进餐刺激有关；T2DM 患者口服葡萄糖后 GLP-1的分泌水平可能与血糖水平、胰岛功能、胰岛素抵抗相关。