抗抑郁治疗对抑郁症患者视觉反应时间的影响

摘要

Objective To explore the effects of antidepressant treatment on visual reaction time of patients with depressive disorder. Methods 32 patients met the Chinese classification and diagnostic criteria of mental disorders-3(CCMD-3) for depressive disorder were selected as depression group and treated with paroxetine. Hamilton depression scale 17(HAMD-17) was used to evaluate their depressive symptoms, EP102-1 multi-functional reaction time analyzer and computer reaction time measurement software system were employed to detect their visual reaction time before treatment and 8 weeks after treatment. Another 32 staffs and students with similar age,gender and education to patients in depression group were chosen as control group. Results After treatment in depression group, HAMD-17 scores of patients were significantly lower, and detection indexes of visual simple reaction time and complex reaction time were shorter than those before treatment(P＜0.01). But the mean and the shortest reaction time of patients in depression group were still shorter than those in control group(P＜0.05), and the longest reaction time and error reaction rates of them showed no statistically significant difference when compared with those in control group(P＞0.05). Conclusion The detection indexes of reaction time can reflect condition of patients with depressive disorder to some extent.%目的 探讨抗抑郁治疗对抑郁症患者视觉反应时间的影响.方法 选择32例符合中国精神障碍分类与诊断标准第3版(CCMD-3)抑郁症诊断标准的患者作为抑郁组采用帕罗西汀治疗,治疗前和治疗8周末采用汉密尔顿抑郁量表-17 (HAMD-17)评定其抑郁症状,EP102-1型多功能反应时间测定仪与计算机反应时间测定软件系统检测视觉反应时间.选择年龄、性别、文化程度相似的单位职工和学生32名作为对照组.结果 抑郁组患者治疗后,HAMD-17评分较治疗前明显降低,视觉简单反应时间及复杂反应时间的检测指标较治疗前明显缩短(P＜0.01),但抑郁组患者平均反应时间及最快反应时间仍比对照组慢(P＜0.05),最慢反应时间及反应错漏率与对照组比较差异无统计学意义(P＞0.05).结论 反应时间检测指标可在一定程度上反映抑郁症患者的病情.