Objective To investigate the clinical effect by early mechanical ventilation and perfluorocarbons gasification inhala-tion on patients with severe acute pancreatitis (SAP) complicated with acute respiratory distress syndrome (ARDS) .Methods 34 cases of SAP and ARDS patients accepted early mechanical ventilation and vaporization of perfluorocarbon inhalation therapy (ob-servation group) ,and 34 patients received mechanical ventilation for early treatment alone (control group) ,The efficacy ,oxygenation index(PaO2/FiO2 ) and inflammatory cytokines IL-1 ,6 ,8 ,and TNF-a level of two groups were compared .Results The total effi-ciency of the observation group was 94 .12% ,which was significantly higher than the control group that was 76 .47% (P<0 .05) . After treatment ,the arterial oxygen saturation (SaO2 ) ,arterial oxygen pressure (PaO2 ) ,PaO2/FiO2 of the observation group in-creased significantly ,and higher than the control group(P<0 .05) .After treatment ,IL-1 ,6 ,8 ,TNF-αof the observation group were significantly lower than the control group(P<0 .05) .Conclusion The treatment of early mechanical ventilation with perfluorocar-bon inhalation gasification could control the inflammation in patients with SAP complicated with AROS ,which could improve the cure rate .%目的：探讨重症急性胰腺炎（SAP）合并急性呼吸窘迫综合征（ARDS）患者应用早期机械通气联合全氟化碳气化吸入的临床疗效。方法34例SAP合并ARDS患者接受早期机械通气及全氟化碳气化吸入治疗（观察组），34例接受单纯行早期机械通气治疗（对照组），观察两组临床疗效，氧合指标（PaO2/FiO2），白细胞介素（IL ）-1、6、8，肿瘤坏死因子-α（T N F-α）的差异。结果观察组总有效率（94．12％）显著优于对照组（76．47％）（P＜0．05）。治疗后，观察组动脉血氧分压饱和度（SaO2）、动脉血氧分压（PaO2）、PaO2/FiO2显著上升，且高于对照组（P＜0．05）。治疗后观察组IL-1、6、8，TNF-α显著低于对照组（P＜0．05）。结论早期机械通气联合全氟化碳气化吸入能有效控制SAP合并ARDS患者炎性反应的发生，提高治愈率。
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