凹叶瑞香中的香豆素成分

摘要

AIM:To study the chemical constituents on the stems and barks of Daphne retusa.METHODS:Compounds were separated by column chromatography with silica gel,Sephadex LH-20 and RP18 silica gel.Their structures were elucidated on the basis of physiochemical and spectral analyses.RESULTS:Eight compounds were isolated from D.retusa,and their structures were identified as 7-hydroxycoumarin (1),7-methoxy-8-hydroxycoumarin (2),7-hydroxy-8-methoxycoumarin (3),daphnoretin-7-O-β-D-glucoside (4),umbeliferone-7-O-β-D-glucoside (5),edgeworside A and C (6 and 7),and [8,8'-bi-2H-1-henzopyran]-2,2'-dione,7'-(α-D-glucopyranosyloxy)-7-hydroxyl-3-[(2-oxo-2H-l-benzopyran-7-yl)oxy](8).CONCLUSION:Compounds 1～8 have been isolated from this plant for the first time.%目的:对凹叶瑞香(Daphne retusa)的化学成分进行研究.方法:利用硅胶柱色谱,Sephadex LH-20和RP18反相柱色谱的方法分离和纯化化合物,通过光谱方法及理化性质鉴定化合物结构.结果:从凹叶瑞香氯仿部位分离得到8个香豆素类成分,分别为7.羟基香豆素(1),7-甲氧基-8-羟基香豆素(2),7.羟基.8.甲氧基香豆素(3),双白瑞香素-7-O-β-D-葡萄糖苷(4),伞形花内酯-7-O-β-D-葡萄糖苷(5),结香苷A和C(6和7),[8,8'-bi-2H-1-benzopyran]-2,2'dione,7'-(a-D-glucopyranosyloxy)-7-hydroxy-3-[(2-oxo-2H-1-benzopyran-7-y1)oxy](8).结论:所有化合物均为首次从该植物中分得.