目的:比较研究鼻腔淋巴瘤调强放疗(IMRT)和半野照射对靶区及其周围危及器官受照剂量的差异.方法:随机选择8例鼻腔淋巴瘤患者,进行CT扫描、靶区和危及器官的勾画,用三维治疗计划系统进行调强和半野照射的计划设计,并对结果进行比较分析.结果:调强计划对靶区适形度优于半野照射,差异具有统计学意义(P＜0.005).IMRT比半野照射能更好地保护某些正常组织,减少眼球、脑干、垂体和颞颌关节等正常组织的照射剂量(P＜0.05),而对晶体、视交叉和视神经等正常组织2种计划无显著差异(P＞0.05).结论:在鼻腔淋巴瘤放疗中,IMRT较半野照射技术在剂量学方面有一定的优越性.%Objective To compare the dosimetric differences of the planning target volume(PTV) and the organs at risk (OAR) for postoperative patients with nasal lymphoma on intensity -modulated radiotherapy(IMRT) and mono -isocenter irradiation. Methods Eight postoperative patients with nasal lymphoma were chosen randomly. The next steps were CT scan, PTV and OAR contouring. The treatment protocols were designed into mono-isocenter irradiation and IMRT by TPS. Finally, the dose distribution and DVH were compared. Results About the conformability of PTV, IMRT showed a significantly superior dose distribution and the differences(P<0.005) have statistical significance. As compared with mono-isocenter irratiation, IMPT could protect some normal tissues, the received dose(P<0.05) of normal tissues were reduced including eyeball, brain stem, pituitary and temporomandibular joint, but with no obvious differences for crystal, optic chiasma and optic nerve(P>0.05). Conclusion In postoperative radiotherapy for nasal lymphoma, IMPT has more dosimetric advantages over mono -isoeenter irradiation technique in radiotherapy.
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