微囊化周围神经组织腹腔移植的实验研究

摘要

目的 观察微囊化周围神经组织移植体内后的生物活性,分析其在体内存活的时效. 方法 采用注射的方法 将微囊化周围神经组织移植到小鼠的腹腔. 结果 微囊化周围神经组织移植6周后,在小鼠的腹腔内保持了原有的形状和结构,囊内的细胞正常生存并保持增殖功能. 结论 微囊化神经组织可在体内保持活性至少6周,完善微囊化技术有望延长其存活时效,提高其促进神经损伤修复的效果.%Objective To study bioactivity of microencapsulated peripheral nerve tissue after transplanted into abdominal cavity and analyze the in vivo time-effect relation. Methods Microencap-sulated peripheral nerve tissues were injected into the abdominal cavity of mice. Results Microencap-sulated peripheral nerve could remain intact six months after transplantation. The peripheral nerve cells survived, with normal proliferation function. Conclusions Microencapsulated peripheral nerve tissues can remain bioactivity at least six weeks in vivo. Improved technique of microencapsulation may prolong bioactivity of microencapsulated peripheral nerve tissues and accordingly promote nerve regeneration fol-lowing peripheral nerve injury.