重复经颅磁刺激对阿尔茨海默病患者认知功能的影响

摘要

目的：探讨重复经颅磁刺激（rTMS）对阿尔茨海默病（AD）患者认知功能的影响。方法：AD患者60例随机分为rTMS组和对照组各30例，对照组患者给予口服奥拉西坦药物治疗，rTMS组加用20Hz rTMS治疗。治疗前后采用简易智力状况评分（MMSE）、蒙特利尔认知评分（MoCA）、阿尔茨海默病评定量表认知部分（ADAS‐Cog）进行疗效评估。结果：治疗16周后，rTMS组的MMSE评分、MoCA总分及各项目评分均明显高于治疗前及对照组（P＜0．05），ADAS‐Cog量表总分及各项目评分均明显低于治疗前及对照组（P＜0．05）；对照组各项评分治疗前后比较差异无统计学意义。结论：rTMS对促进阿尔茨海默病患者认知功能的恢复有明显作用。%Objective:To study the effect of repetitive transcranial magnetic stimulation (rTMS) on the learning and memory function in patients with Alzheimer disease (AD) .Methods:Sixty patients with AD were randomly and equally assigned to rTMS group and control group (n=30 each) .The patients in control group were treated with pi‐racetam for 16 weeks ,and those in rTMS group were treated with 20Hz rTMS .Before and after treatment ,the pri‐mary efficacy was evaluated by using the Mini‐Mental Status Examination (MMSE) ,the Alzheimer Disease Assess‐ment Scale cognition (ADAS‐cog) and Montreal Cognitive Assessment (MoCA) .Results:The scores of MoCA and MMSE scale in rTMS group were significantly higher than before treatment and the control group (P<0 .05) .The scores of ADAS‐cog scale in rTMS group were obviously lower than before treatment and the control group (P<0 .05) .There was significant difference in the scores of MoCA and MMSE scale and the scores of ADAS‐cog scale before and after treatment in the control group .Conclusions:rTMS treatment can improve memory and cognitive functions in patients with AD .