脑蛋白水解物对高原地区缺氧缺血脑病新生儿血清超敏C反应蛋白、胰岛素样生长因子1和白细胞介素-18的影响

摘要

目的：研究脑蛋白水解物对高原地区新生儿缺氧缺血脑病(HIE)患儿疗效及血清中超敏C反应蛋白(hsCRP)、胰岛素样生长因子-1(IGF-1)和白细胞介素-18(IL-18)水平的影响。方法2013年1月~2015年5月本科收治的HIE患儿104例，随机分为常规治疗组(n=52)和脑蛋白水解物治疗组(n=52)，另选取35名健康新生儿作为对照组。观察治疗前后患儿血清中hsCRP、IGF-1、IL-18水平及临床疗效。结果与对照组和轻度HIE组比较，中、重度HIE组患儿IGF-1水平下调(P<0.05)，hsCRP、IL-18水平上调(P<0.05)。治疗后，脑蛋白水解物治疗组总有效率大于常规治疗组(χ2=8.922, P=0.012)。与常规治疗组比较，脑蛋白水解物治疗组治疗后血清中IGF-1水平上升，hsCRP、IL-18浓度下降(P<0.05)。结论脑蛋白水解物对高原地区HIE患儿疗效显著。血清hsCRP、IGF-1、IL-18水平变化可作为HIE患儿早期诊断的辅助指标。%Objective To investigate the effect of cerebroprotein hydrolysate on the serum high sensitivity C reactive protein (hsCRP), insulin-like growth factor-1 (IGF-1) and interleukin-18 (IL-18) in patients with hypoxic ischemic encephalopathy (HIE) in plateau region. Methods From January, 2013 to May, 2015, 104 cases with neonatal HIE in our department were randomly divided into conventional treat-ment group (n=52) and cerebroprotein hydrolysate group (n=52). Besides, 35 cases of healthy newborn were chosen as the control group. The total effective rate and the serum hsCRP, IGF-1, IL-18 levels were compared. Results The IGF-1 level was lower, and the levels of hsCRP and IL-18 were higher in moderate HIE group and severe HIE group than in the control group and the mild HIE group, respectively (P<0.05). The efficiency rate was significantly higher in the cerebroprotein hydrolysate group than in the conventional treatment group (χ2=8.922, P=0.012). Compared with the conventional treatment group, the IGF-1 level increased, and the levels of hsCRP and IL-18 decreased in the cerebroprotein hydrolysate group (P<0.05). Conclusion Cerebroprotein hydrolysate is effective on patients with HIE in plateau re-gion. The changes of serum hsCRP, IGF-1, and IL-18 levels can be used as auxiliary indexes for early diagnosis of HIE.