Effect of Cerous Nitrate on NOS Activity and iNOS mRNA Level in Rat Liver

摘要

The effect of cerous nitrate on activity of NOS and expression of iNOS in rat hepatocyte was studied by means of reverse transcription polymerase chain reaction (RT PCR). The result shows that neither high (50 mg·kg -1 ) nor low(1 mg·kg -1 ) dose of cerous nitrate can induce the increase of expression of iNOS mRNA, but an increase of activity was observed after administration of cerous nitrate. Possible mechanism for these phenomena was discussed.