Saw Palmetto Extract Enhances Erectile Responses by Inhibition of PDE5 Activity and Increase in iNOS mRNA Expression in Rat and Rabbit Corpus Cavernosmn

首页> 中文期刊> 《中国药理学会通讯》 >Saw Palmetto Extract Enhances Erectile Responses by Inhibition of PDE5 Activity and Increase in iNOS mRNA Expression in Rat and Rabbit Corpus Cavernosmn

Saw Palmetto Extract Enhances Erectile Responses by Inhibition of PDE5 Activity and Increase in iNOS mRNA Expression in Rat and Rabbit Corpus Cavernosmn

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《中国药理学会通讯》 |2013年第4期|22-23|共2页
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正文语种 chi
中图分类中药实验药理;
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棕榈提取物; 海绵体; 生理盐水; 医学实验;

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1. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004）（P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
2. ACUPUNCTURE EFFECT ON GENE EXPRESSION OF c-fosmRNA, ppENKmRNA, iNOSmRNA AND iNOS ACTIVITY IN THE MOUSE SPINAL CORD [J] . 刘清 ,吴景兰 . 世界针灸杂志：英文版 . 2000,第1期
3. Bone Regeneration Enhanced by Antigen-Extracted Xenogeneic Cancellous Bone Graft with rhBMP-2 in Rabbits Mandibular Defect Repair [J] . Renfa Lai ,Zejian Li ,Ye Zhang . 工程（英文）（1947-3931） . 2013,第10期
4. Increased inflammatory cell infiltration and matrix metalloproteinase-1 expression in atherosclerotic plaque of diabetic rabbits [J] . Albert FERRO . 上海医学 . 2007,第S1期
5. Maturation of Cordyceps sinensis associates with increased expression of Paecilomyces hepiali gene and altered differential expressions of 2 forms of Hirsutella sinensis genes [C] . Jia-Shi Zhu ,Yisang Yao ,Yanjiao Zhou . 2008全国药用真菌学术研讨会 . 2008
6. A Corpus Based Study of Chinese Stock Expressions [A] . 张艳 . 2012

Saw Palmetto Extract Enhances Erectile Responses by Inhibition of PDE5 Activity and Increase in iNOS mRNA Expression in Rat and Rabbit Corpus Cavernosmn

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