目的：探讨三阴性乳腺癌的临床病理学特征及预后特点。方法选择2010年1月至2012年12月西平县人民医院收治的乳腺癌患者90例，将HER-2、PR、ER均为阴性的52例分为三阴组，其他38例分为非三阴组，对比分析两组病理学特征、复发、生存状况等。结果三阴组52例患者中，26例绝经，4例有家族史，47例属于临床Ⅱ、Ⅲ期，8例肿瘤直径在5 cm以上，9例组织学分级为Ⅲ级，31例浸润性导管癌，3例浸润性小叶癌，23例病理高度分化，16例有腋窝淋巴结转移。经随访，复发25例，远处转移30例，死亡7例，其中三阴组复发率（36.54%）明显高于非三阴组复发率（15.79%），三阴组远处转移率（42.31%）明显高于非三阴组远处转移率（21.05%），差异有统计学意义（P﹤0.05）。结论三阴性乳腺癌是一种独特的亚型，组织分化程度高，多数为浸润性导管癌，其复发率、转移率均较高，整体预后较差。%ObJective To investigate clinical pathological features and prognosis of patients with triple negative breast cancer. Methods Ninety patients with breast cancer in the people’s hospital of Xiping from January 2010 to De-cember 2012 were selected as study objects,52 cases of HER-2,PR,ER-negative were divided into triple negative group and other 38 cases were divided into non-triple-negative group. The pathological features,recurrence,survival status of the two groups were analyzed. Results In 52 cases of triple negative group,26 cases of menopause,4 cases with family histo-ry,47 cases at the clinical stage Ⅱ,Ⅲ,8 cases of cancer than more 5 cm in diameter,9 cases of histological gradeⅢ, 31 cases of invasive ductal carcinoma,3 cases of invasive lobular carcinoma,23 cases of pathological highly differentiated, 16 cases with axillary lymph node metastasis. After follow-up,25 cases of recurrence,30 cases of distant metastasis,7 ca-ses of death,the recurrence rate of triple-negative group(36. 54%)was significantly higher than non-triple-negative group (15. 79%),distant metastasis rate of triple-negative group(42. 31%)was significantly higher than non- triple-negative group(21. 05%)(P﹤0. 05). Conclusions Triple negative breast cancer is a unique subtype,a high degree of differen-tiation,the majority of invasive ductal carcinoma,the recurrence rate,higher transfer rates,the overall prognosis is poor.
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