PET serves as one of the most advanced imaging modalities,and its development depends on the improvement of radiotracers.Among numerous positron isotopes,18 F appears to be the best radionuclide candidate for PET radiotracers by virtue of its favorable physical characteristics.18 F-labeled aromatic radiotracers have been widely investigated by researchers due to its special metabolic stability.However, the development and application of 18 F-labeled aromatic radiotracers have been limited due to lacking of radiochemical methods to obtain products with high selectivity,high radioactivity and high purity.This review focuses on the new labeling methods of 18 F-labeled aromatic radiotracers from the aspects of electrophilic and nucleophilic substitution reactions.%PET显像技术是先进的显像技术之一,其发展与正电子核素标记的PET显像剂密切相关.在众多正电子核素中,18F具有理想的物理性质,成为PET显像剂中最常用的核素.18F标记芳环类PET显像剂因其特殊的代谢稳定性而受到重视.然而,由于缺乏高选择性、高放射性产率和高纯度产物的18F标记方法,18F标记芳环类显像剂的发展和应用受到一定限制.该文从芳环的亲电以及亲核取代反应等方面,对18F标记芳环类显像剂新的标记方法进行综述.
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