早中期帕金森患者的杂乱生物运动感知障碍

摘要

目的：探讨帕金森病（Parkinson disease,PD）患者的杂乱生物运动感知能力。方法30例原发性PD患者以及与其人口学资料相匹配的正常对照组作为研究对象，采用生物运动的时距辨别任务（a duration dis⁃crimination task）进行杂乱生物运动感知能力测试。采用Hoehn-Yabr(H-Y)分级量表对PD患者的严重程度进行评定。结果与检验值“0”相比，正常对照组的主观相等点（the point of subjective equality, PSE）（-0.15±0.18）为负值，差异有统计学意义（t=4.56,P<0.001）。PD患者的PSE（0.04±0.21）与正常对照组的PSE相比，负值消失，差异有统计学意义（t=3.72, P<0.001）。PD 患者组按病情严重程度分为2亚组，PD早期组（H-Y 1~2级）的PSE （0.02±0.26）和PD中期组（H-Y 2.5~3级）的PSE（0.06±0.12）与正常对照组相比，差异均有统计学意义（PD早期组：P<0.01；PD中期组：P<0.01）。PD早期组和PD中期组的PSE之间无明显差异(P=0.61)。结论 PD患者在病程的早期即出现杂乱生物运动感知能力障碍，这种感知障碍可能与前额叶功能异常有关。%Objective To explore scrambled biological motion perception in Parkinson’s disease (PD). Meth⁃ods Thirty individuals with idiopathic PD and matched health controls (HCs) underwent discrimination task.The severi⁃ty of disease was assessed based on the Hohen and Yahr scale. Results Compared with“PSE=0”,there was a significant negative PSE (the point of subjective equality) (-0.15 ± 0.18) for HCs ( t=4.56, P<0.001), suggesting a temporal dilation effect of the upright scrambled biological motion sequences in HCs. There was a significant difference in the PSE be⁃tween PD patients(t=3.72,P<0.001) and HCs. Patients in the PD group were then divided into two subgroups accord⁃ing to their status of disease. There were significant differences in PSE between early-stage PD patients (stage 1-2) (0.02±0.26) and HCs (P<0.01), and between mid-stage PD patients (stage 2.5-3) (0.06±0.12) and HCs (P<0.01). There was no significant difference in PSE between early-stage and mid-stage PD patients (P=0.61). Conclusion The present study suggests that there is a scrambled biological motion perception impairment in PD at the very early stage, which might be attributed to the dysfunction of the prefrontal lobe.