抗真菌药物的联合应用

摘要

目前真菌感染,特别是免疫缺陷患者中侵入性真菌感染的发病率和死亡率在不断增加,但现有抗真菌药物可选择范围小、毒副作用大而且耐药情况日渐严重.联合用药这一概念的提出,给耐药株及严重性真菌感染提供了新的治疗途径,并且已在临床中广泛运用.该文对不同种类抗真菌药物联用的研究成果及作用机制做一综述.%Nowadays, morbidity and mortality of invasive fungal infection are increasing, especially among immunocompromised patients. However, the range of choices of existing antifungal drugs, most of which have drug toxicities and drug resistance, are limited. The combination use of antifungal drugs which has gradually applied to the clinic provides a new approach for the resistant strains infection and severe fungal infection. This review is about the effects and mechanisms of the combination therapy of different antifungal drugs.