Drug Interaction of Combined Use of Nerve Agent Pretreatment with Anesthetics, Analgesics and Other Battlefield Medications

摘要

Pyridostigmine is a drug stockpiled for pretreatment of nerve agent exposure. There is a need to know potential interactions of pyridostigmine with other drugs likely to be encountered by a combat casualty. A comprehensive search of existing literature on pyridostigmine and selected drugs contained in the Defense Medical Standardization Board D-Day Items List was completed. IT appears that the only significant interaction might be with neuromuscular blocking drugs used in anesthesia, which in turn could pose the greatest casualty management concerns. For this reason, it is recommended that the possible changes in responses to neuromuscular blockers in soldiers taking pyridostigmine over a period of time be investigated further.