去乙酰化酶Sirtuins和细胞衰老与动脉粥样硬化的研究进展

摘要

细胞衰老是由自身老化或外部刺激诱发的细胞周期停滞.动脉粥样硬化是冠心病的基本病理生理学特征.最新研究发现,细胞衰老是动脉粥样硬化发生发展的重要机制之一.Sirtuins是一类能够调节细胞新陈代谢并参与多种细胞生理功能的去乙酰化酶.以往研究已经揭示了Sirtuins的抗衰老作用,认为Sirtuins是一种与长寿相关的蛋白,可通过调节细胞衰老使动脉粥样硬化得到抑制或逆转.基于此,本文回顾了Sirtuins 和细胞衰老与动脉粥样硬化的最新研究发现,并探讨Sirtuins 活化作为动脉粥样硬化治疗新靶点的可行性.%Cellular senescence is cell cycle stagnation caused by chronological aging or external stimulation.Atherosclerosis is regarded as the basic pathophysiological feature of coronary heart disease.Recent studies have found cellular senescence is an important mechanism for the development of atherosclerosis.Sirtuins, a family of cellular deacetylases, regulate the metabolism of cells and participate in the physiological functions of various cells.Previous studies have revealed the anti-ageing effect of Sirtuins, and suggested that Sirtuins are a group of longevity-associated proteins that can inhibit or reverse atherosclerosis by regulating cell aging. Herein,we reviewed the recent studies concerning Sirtuins,cellular aging and atherosclerosis,and discuss the feasibility of activating Sirtuins as a new strategy for combating atherosclerosis.