脊柱后纵韧带骨化的基因学研究进展

摘要

脊柱后纵韧带骨化的发生是由环境、基因等多因素造成的。随着基因学研究的深入，目前认为基因突变是诱发后纵韧带骨化的重要因素。尽管目前在后纵韧带骨化疾病的基因学研究方面取得了一定的进展，但是仍然还未有确切基因显示与后纵韧带骨化关系密切，后纵韧带骨化的发病机制还需要进一步的探索。%[Summary] The ossification of the posterior longitudinal ligament ( OPLL ) is caused by environmental , genetic and other factors.With the development of genomics research , researchers have found that mutations are important factors inducing OPLL . Despite the genomics research on OPLL has made important advances , no highly correlation has been found between OPLL and the exact single nucleotide polymorphisms (SNPs) loci.The pathogenesis of OPLL needs further exploration .