儿童甲状旁腺功能减退症36例临床特点分析并文献复习

摘要

Objective To analyze the clinical feature of hypoparathyroidism in order to deepen the understanding of the disease. Method A retrospective analysis of the clinical data of 36 patients with hypoparathyroidism. Result In 36 patients, 19 were males and 17 were females;age of onset from 3 days to 12 years old, time of onset to diagnosis was 8 days to 14 years. Mainly manifestations included tetany and convulsions. Some patients complained of chest tightness and pain. Laboratory examinations revealed hypocalcemia and hyperphosphatemia. The level of alkaline phosphatase was normal or slightly elevated. The incidence of intracranial calcification was high. After treated with calcium and calcitriol, the manifestation improved. Conclusion Children with seizures and chest tightness should be routinely detected blood calcium and phosphorus. To strengthen the understanding of hypoparathyroidism in order to avoid the misdiagnosis.%目的：分析儿童甲状旁腺功能减退症的临床特点，以提高对本病的认识。方法回顾性分析了36例甲状旁腺功能减退症儿童病例资料。结果36例患者中男19例，女17例；发病年龄在3天至12岁，发病到确诊时间为8天至14年；主要表现为手足搐搦和惊厥，部分胸闷胸痛起病。实验室检查均为低钙血症、高磷血症、碱性磷酸酶正常或轻度升高。颅内钙化发生率高，对钙剂及骨化三醇治疗反应良好。结论对惊厥及胸闷儿童应常规行血钙、血磷检查，提高对甲状旁腺功能减退症的认识，以免误诊误治。