血小板反应性对冠心病合并高尿酸血症患者冠脉介入治疗术后不良心血管事件的预测

摘要

目的:探讨血小板反应性对冠心病合并高尿酸患者冠脉介入治疗术后发生不良心血管事件的预测价值.方法:回顾性分析PCI术的冠心病患者593例,并按血尿酸水平分为高尿酸血症组213例及对照组380例,患者于术后7天行血栓弹力图检测,比较两组患者血小板花生四烯酸(AA)聚集率及血小板二磷酸腺苷(ADP)聚集率,观察介入治疗术后1年不良心血管事件.结果:高尿酸血症组患者AA及ADP诱导的血小板聚集率高于对照组,差异有统计学意义(P<0.05).结论:血小板反应性与PCI术后MACE的关系在冠心病合并高脂血症患者中要强于对照组.%Objective: To study the value of platelet reactivity in predicting major adverse cardiovascular events (MACE) in hyperuricemia patients with coronary heart disease (CHD) after percutaneous coronary intervention(PCI).Methods: Clinical data of 593 patients following PCI were retrospectively analyzed.The patients were divided into hyperuricemia group (n=213) and control group (n=380) according to their serum uric acid level.Their platelet AA aggregation rate (AA%) and ADP aggregation rate (ADP%) were assayed by thrombelastography.The incidence of major adverse cardiovascular events (MACE) after PCI in one year was record.Results: The ADP% and AA% were significantly higher in hyperuricemia group than in control group(P<0.05).Conclusion: The association between platelet reactivity and MACE after PCI is closer in hyperuricemia patients with CHD than in control group.