小剂量盐酸替罗非班联合急诊冠脉介入在心肌梗死患者中的临床效果及安全性

摘要

目的:综合分析小剂量盐酸替罗非班联合急诊冠脉介入在心肌梗死患者中的临床效果及安全性,为治疗心肌梗死患者提供科学的数据参考.方法:选取2013年10月～2016年10月收治的110例心肌梗死患者,根据患者的意愿随机分为试验组(应用小剂量盐酸替罗非班联合急诊冠脉介入治疗方法)与对照组(应用急诊冠脉介入治疗方法联合常规剂量盐酸替罗非班),每组均为55例.采用SPSS 20.0统计学软件进行统计学分析两组患者的发病至介入时间、心血管发生情况、出血并发症发生率以及急诊冠脉介入手术前后TIMI血流分级情况.结果:(1)两组患者在发病至介入时间比较无统计学意义(P＞0.05);(2)试验组患者住院期间心血管发生率为0.00％(0/55),对照组患者住院期间心血管发生率为7.28％(4/55),试验组患者住院期间心血管发生率显著低于对照组患者(P＜0.05);(3)急诊冠脉介入手术前,两组患者在TIMI 2级和TIMI 3级比较无统计学意义(P＞0.05),在TIMI 0级和TIMI 1级比较有统计学意义(P＜0.05),急诊冠脉介入手术后,两组患者在TIMI 0～2级、TIMI 3级比较有统计学意义(P＜0.05).结论:小剂量盐酸替罗非班联合急诊冠脉介入在心肌梗死患者中的临床效果显著且具有高度的安全性.%Objective To analyze the clinical efficacy and safety of low dose tirofiban hydrochloride combined with emergency coronary intervention in patients with myocardial infarction,and to provide reference data for the treatment of patients with myocardial infarction.Methods Admitted to the Second Affiliated Hospital of Xi'an Medical University between October 2013 and October 2016,110 patients with myocardial infarction were randomly divided into experimental group and control group,with 55 patients in each group.The patients in experimental group were treated with low dose tirofiban hydrochloride combined with emergency coronary intervention,while those in control group received emergency coronary intervention therapy combined with conventional dose tirofiban hydrochloride.SPSS 20.0 statistical software was used to analyze the time between onset and intervention,the occurrence of cardiovascular diseases,the incidence of bleeding complications and the thrombolysis in myocardial infarction (TIMI) blood flow before and after emergency coronary intervention.Results No significant differences were found between two groups in the time between onset and intervention (P＞0.05).The incidence of cardiovascular disease in experimental group was 0.00％ (0/55) as compared with 7.28％ (4/55) in control group,with statistical differences (P＜0.05).Before emergency coronary intervention,the comparison between two groups showed significant differences in TIMI grade 0 and 1 (P＜0.05),but not in TIMI grade 2 and 3 (P＞0.05).After emergency coronary intervention,two groups had significant differences in TIMI grade 0-2 and 3 (P＜0.05).Conclusion Low dose tirofiban hydrochloride combined with emergency coronary intervention in patients with myocardial infarction has significant clinical efficacy and high safety.