动态增强磁共振成像定量评估健康志愿者胰腺灌注的可行性

摘要

Objective To explore the feasibility of quantitative assessment of pancreatic perfusion using dynamic contrastenhanced MRI (DCE-MRI).Methods Totally 68 healthy volunteers were divided into youth,middle and old groups according to ages.All volunteers underwent pancreas DCE-MRI examination.Images were transmitted to Research-DCE MRI Tool workstation to calculate the quantitative parameters,including volume transfer constant (Ktrans),interstitium-toplasma rate constant (Kep),interstitial volume (Ve) and plasma volume (Vp).Independent sample t test and one-way ANOVA test were used to evaluate the differences of pancreatic perfusion.Results There were no significant differences of Ktrans,Kep, Ve and Vp between male and female;Ve in old group was higher than that in youth and middle groups (P =0.036,0.001);Vp of pancreatic head was higher than that of pancreatic body and tail (P=0.011,0.023).Conclusion DCE-MRI can be applied to provide a reliable quantitative assessment of pancreatic perfusion noninvasively.The parameters of DCE-MRI of pancreatic perfusion are independent of gender but vary with age and pancreatic sites.%目的 探讨动态增强磁共振成像(DCE-MRI)量化评估胰腺灌注的可行性.方法 将68名健康志愿者分为青年组、中年组和老年组.对所有志愿者均行DCE-MRI,将数据传至Research-DCEMRI Tool诊断分析工作站,计算胰腺灌注的定量参数:容积转运常数(Ktrans)、间质-血浆速率常数(Kep)、间质容积(Ve)和血浆容积(Vp).采用两独立样本t检验和单因素方差分析评估不同性别、年龄组和胰腺部位的灌注参数.结果不同性别志愿者Ktrans、Kep、Ve和Vp差异均无统计学意义(P均＞0.05);老年组Ve高于青年组和中年组(P=0.036、0.001);胰头区Vp高于胰体部和胰尾部(P=0.011、0.023).结论 DCE-MRI可无创、较稳定、定量评估胰腺灌注情况.胰腺DCE-MRI定量灌注参数不随性别差异而不同,但随年龄和胰腺部位的不同而有差异.