Objective To explore the protective effects of Shenlongjiannao capsule on rats with cerebral ischemia. Methods The cerebral ischemia animal model was established by two-vessel occlusion. Fifty rats were randomly divided into 5 groups: control group with sham operation, model group, positive control group of pisacetam, Shenlongjiannao capsule groups (low and high dosage). Four weeks later, SOD, · OH, MDA and AchE in cortex was measured. Result Shenglongjiannao capsule decreased the contents of MDA and·OH in cortex of cerebral ischemia rats, and improved activities of SOD and AchE. Conclusion Shenlongjiannao capsule may play protective role on rats with chronic cerebral ischemia.%目的 探讨参龙健脑胶囊对脑缺血大鼠的脑保护作用.方法 利用双侧颈总动脉结扎制备慢性脑缺血模型,选50只大鼠分为假手术组、模型组、脑复康阳性对照组及参龙健脑胶囊大、小剂量组.各给药组以相应药物灌胃,假手术组,模型组予生理盐水灌胃.4周后测定各组大鼠大脑皮层羟自由基(·OH)、超氧化物歧化酶(SOD),丙二醛(MDA)和乙酰胆碱酯酶(AchE)的含量.结果 参龙健脑胶囊可明显降低脑缺血大鼠大脑皮层·OH和MDA的含量,提高SOD和Ache的活性.结论 参龙健脑胶囊对大鼠慢性脑缺血有明显的保护作用.
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