活动期溃疡性结肠炎患者血小板功能与凝血纤溶功能的变化

摘要

Objective To evaluate the changes of platelet function, coagulation-fibrinolysis status in active phase UC patients and the relationship between the function change and different clinical types of UC, discuss the correlation of the indexes. Methods Ninety-one UC patients were divided into 3 groups: mild group, moderate group and severe group;while 200 healthy persons were defined as control group. Statistical analysis of platelet count, MPV ( mean platelet volumn), D-dimer, PT (prothrombin time), APTT (activated partial thromboplastin time), fibrinogen were taken among normal control group, UC group and different clinical types of UC group. Indexes with statistical significance would go through correlative tests. Results The platelet count, MPV, D-dimer, fibrinogen were statistically different between control group aud UC group. D-dimer had statistical significence in different severity of the disease. The correlation of D-dimer and fibrinogen ( r = 0. 586972) as well as that of platelet count and fibrinogen ( r = 0. 363792) had statistical significence. Other indexes had no ovbious correlation. Conclusion The platelet count, MPV, D-dimer and fibrinogen may become predictors in active phase UC patients, and D-dimer can reflect the severity of ulcerative colitis.%目的 研究活动期溃疡性结肠炎(ulcerative colitis,UC)患者的血小板功能及凝血纤溶功能的改变及其与病情严重程度的关系,并探讨各指标间变化的相关性.方法 收集91例活动期UC住院患者与200名正常体检者进行血小板数量、血小板平均体积、凝血酶原时间、活化凝血酶原时间、D二聚体、纤维蛋白原检测,分别进行患病组与正常对照组、不同病情严重程度间的指标统计学分析,对差异具有统计学意义的指标进行相关性分析.结果 活动期UC患者与正常对照组的血小板数量(P<0.05)、血小板体积(P<0.01)、D-二聚体(P<0.01)和纤维蛋白原(P<0.05)差异具有统计学意义,其余指标差异无统计学意义.根据病情严重程度不同,D二聚体的变化差异具有统计学意义.对差异具有统计学意义的指标进行相关性分析,D二聚体与纤维蛋白原的相关性高(r=0.586972),并且具有统计学意义(P<0.01),另外血小板数量和纤维蛋白原的相关性也同样具有统计学意义(P<0.01),其余指标间无明显相关性.结论 血小板数量、血小板体积、D二聚体、纤维蛋白原异常可作为疾病活动期的预测指标,D二聚体可随病情加重而增加.