自发性细菌性腹膜炎易感因素的研究

摘要

Objective To investigate the predisposing factors of spontaneous bacterial peritonitis in patients with liver cirrhosis.Methods The clinical data of forty-five liver cirrhosis patients with SBP and forty-five liver cirrhosis patients without SBP in Renmin Hospital of Wuhan University from Jun.2014 to Jun.2016 were collected.Results Patients with liver cirrhosis who had the history of SBP were more possible suffered from SBP (OR =2.574,95％ CI:1.534 ～ 6.386);patients with liver cirrhosis who were older than 60 years old were more possible suffered fiom SBP (OR =1.019,95％ CI:1.022 ～ 1.178).Patients with liver cirrhosis who had the history of gastrointestinal hemorrhage were more possible suffered from SBP (OR =1.795,95％ CI:1.139 ～5.112).Conclusion The predisposing factors of spontaneous bacterial peritonitis in patients with liver cirrhosis are the history of SBP,older than 60 years old and the history of gastrointestinal hemorrhage.%目的 探讨肝硬化患者发生自发性细菌性腹膜炎(spontaneous bacterial peritonitis,SBP)的易感因素.方法 选取2014年6月-2016年6月在武汉大学人民医院消化内科住院治疗且符合纳入标准的肝硬化SBP患者45例,选择同期住院的肝硬化非SBP患者45例,收集并分析两组患者的临床资料.结果 有SBP感染史的患者再次发生SBP的风险是无SBP感染史患者的2.574倍(OR=2.574,95％ CI:1.534 ～6.386);年龄＞60岁的肝硬化腹水患者发生SBP的风险是年龄≤60岁的肝硬化腹水患者的1.019倍(OR=1.019,95％ CI:1.022 ～1.178);有消化道出血患者发生SBP的风险是无消化道出血患者的1.795倍(OR=1.795,95％CI:1.139～5.112).结论 肝硬化患者发生SBP的易感因素有SBP感染史、年龄＞60岁及消化道出血.