482例艾滋病患者高效抗逆转录病毒治疗效果观察

摘要

Objective To evaluate the treatment effect of AIDS cases with highly active anti-retroviral therapy, provide scientiifc evidence for effective antiviral therapy treatment. Method CD4 +T lymphocyte count, changes of the viral load, incidence of opportunistic infections and cause of death in 482 AIDS patients who received highly active anti-retroviral therapy were retrospectively analyzed. Result The average age of 482 AIDS patients were (35.7±11.0) years old, most were men [318 cases (66.0%)], 337 cases (69.9%) were Uyghur ethnic, HIV infection occurred mainly via sexual contact (60.7%). CD4+T lymphocyte counts increased signiifcantly after treatment for 3, 18, 24 months. There were statistically signiifcant differences in the detection results of CD4+T lymphocyte count between the pre-treatment and the post-treatment for 3, 18 and 24 months (P<0.05). 75.8%patients with the therapy efifciency. Opportunistic infections rate was 57.1%(275/482), most was thrush [31.3%(86/275)]. Fractures mortality was 13.5%, respiratory failure was the primary cause of death. Conclusion It is effective to carry out highly active anti-retroviral therapy on AIDS patients.%目的综合评价高效抗逆转录病毒治疗效果，为改善抗病毒治疗工作提供科学依据。方法回顾性分析接受高效抗逆转录病毒治疗的482例艾滋病患者CD4＋T淋巴细胞计数、病毒载量的变化、机会性感染发生情况以及死亡原因等。结果482例艾滋病患者的平均年龄为（35.7±11.0）岁，多为男性[318例（66.0%）]；337例（69.9%）为维吾尔族，感染途径以性接触（60.7%）为主。CD4＋T淋巴细胞水平在治疗3、18、24个月后均明显上升，与治疗前相比差异具有显著性（P＜0.05）；至2014年6月，继续接受随访的240例患者中，病毒完全抑制例数达182例（75.8%）。机会性感染发生率为57.1%（275/482），主要以鹅口疮[31.3%（86/275）]为主。482例患者死亡65例（13.5%），死因以呼吸衰竭为主。结论高效抗逆转录病毒治疗艾滋病的临床效果较好。