Background Current researches of choroidal structure changes primarily focus on macular choroidal thickness in adolescents and children,but there are few studies on peripapillary choroidal thickness in children with enhanced depth imaging (EDI)-OCT.In addition,the reliability of manual measurements to peripapillary choroidal thickness is an important factor for the estimation of EDI-OCT.Objective This study was to determine the repeatability and reproducibility of manual measurements of peripapillary choroidal thickness in children by EDI-OCT.Methods A reliability evaluation of diagnosis test was performed.EDI-OCT technology was used to image the peripapillary choroidal thickness in 49 children aged 7-14 years in Eye Hospital of Wenzhou Medical University from February to March 2015 under the informed consent of their custodians.An annular scanning was carried out surrounding optical disc by the same ophthalmologist with Spectralis OCT,and the peripapillary choroidal thickness was manually measured at global,temporal,superotemporal,superonasal,nasal,inferonasal and inferotemporal zones.The intraclass and interclass repeatability and reducibility of measuring values from intraobserver,inter-observer and intra-session were evaluated with intraclass correlation coefficients (ICC),and BlandAltman agreement analysis was used to assess the consistency of repeated measurements.Results The average age in the subjects was (9.9 ± 1.3) years.No significant difference was found in the mean difference of reduplicative measured peripapillary choroidal thickness at each zone (all at P＞0.05).The ICCs of intra-observer,inter-observer and intra-session were 0.971-0.993,0.827-0.952 and 0.974-0.991,respectively,and the 95％ limit of agreement of global peripapillary choroidal thickness were-12.4-9.7 μm,-15.2-11.6 μm and-16.3-19.1 μm,respectively.Conclusions The repeatability,reproducibility and consistency are favorable in manually measured values of peripapillary choroidal thickness from EDI-OCT image.EDI-OCT appears a good application in the assessment of peripapillary choroidal thickness in children.%背景 目前关于脉络膜结构变化的研究主要聚焦于成人和儿童黄斑区脉络膜厚度,但鲜见应用增强深部成像(EDI)-OCT技术测量儿童视盘旁脉络膜厚度及其重复性研究的报道,且OCT成像的手动测量结果是否可靠是影响结果判断的主要因素. 目的 对EDI-OCT测量儿童视盘旁脉络膜厚度的可重复性进行评估,探讨其在相关儿童眼病中的应用价值. 方法 采用诊断试验可靠性评价方法,采用EDI-OCT技术对2015年2-3月于温州医科大学附属眼视光医院就诊的49名矫正视力正常的7～12岁儿童进行视盘旁脉络膜厚度测量,受检者平均年龄(9.9±1.3)岁,均任意选择一侧眼作为受检眼.由同一位有经验的医师用Spectralis OCT的EDI模式对受检眼进行以视盘为中心、直径3.4mm区域的环形扫描,测量指标包括测量区全周脉络膜厚度以及颞侧、颞上、鼻上、鼻侧、鼻下和颞下各分区的脉络膜厚度.采取下列3种方法对测量进行重复性和再现性分析:(1)同一测量者2次测量结果的测量者内重复性分析;(2)不同测量者测量结果的再现性分析;(3)同一检查者对2次检测图像测量的检查者内重复性分析.采用组内相关系数(ICC)对重复测量的变异性进行评估,采用Bland-Altman分析对重复测量的一致性进行评估.结果 测量者内重复测量结果、测量再现性结果和检查者内重复测量的平均全周及各分区脉络膜厚度的平均差值差异均无统计学意义(均P＞0.05);测量者内重复测量值、再现性测量值和检查者内重复测量值的ICC分别为0.971 ～ 0.993、0.827 ～0.982和0.974 ～0.991,测量者内重复测量、再现性测量和检查者内重复测量的全周平均视盘旁脉络膜厚度95％一致性界限分别为-12.4 ～9.7 μm、-15.2～11.6μm和-16.3～19.1 μm,这些差值临床上均可以接受.结论EDI-OCT手动测量健康儿童视盘旁脉络膜厚度的可重复性、再现性和一致性均较好,EDI-OCT检测技术在评价儿童脉络膜变化方面具有较好的应用价值.
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