骨保护素、胰岛素样生长因子-1对骨关节炎骨重建作用的研究进展

摘要

骨关节炎(OA)又称为退行性骨关节病,是中老年人常见的慢性病、多发病.OA患者关节疼痛、僵硬、肿大、畸形及功能障碍,严重影响患者生活质量.大骨节病(KBD)是一种以关节软骨变性坏死为主要特征的地方性疾病,发展到晚期成为典型的OA,而KBD和OA又有所不同.骨保护素(OPG)和胰岛素样生长因子(IGF)-1共同参与了骨的生长、修复、改建.以下对OA临床表现、病理改变,OPG和IGF-1在OA骨重建中的作用的现状及发展进行综述.%Osteoarthritis (OA) is a kind of chronic and frequently-occurring disease in the elderly.It is also called degenerative disease.Pain,stiffness,swelling,deformity and dysfunction of joints are the main clinical manifestations,which seriously affect the quality of life.Kaschin-Beck Disease (KBD) is a kind of endemic diseases;its main feature is cartilage degeneration and necrosis.Although KBD becomes a typical OA in late stage,it is different from OA.Osteoprotegerin (OPG) and insulin-like growth factor (IGF)-1 participate in the bone growth,repair,and alteration.In this paper,we summarized clinical manifestations and pathological changes of OA,and reviewed the current situation and development of OPG and IGF-1 in OA bone remodeling.