低频超声与抗菌药物协同增效研究进展

摘要

It is difficult to eradicate bacteria completely with single antibiotic because of serious drug resistance. The combination of low-frequency ultrasound technology and antibiotics could enhance the bactericidal or bacteriostatic effect of antibiotics on both planktonic bacteria and bacterial biofilm. The primary mechanism may be cavitation effect. Currently, low-frequency ultrasound technology has been applied to local infection treatment. As a non-invasive and targeted therapy, low-frequency ultrasound technology has great potential use in clinic. In addition, the low-frequency ultrasound technology has advantage on gene transfection and inhibition of bacterial resistance by changing the genes.%　　细菌耐药日益严重，单一抗菌药物难以完全杀灭耐药菌。应用低频超声技术联合抗菌药物，无论是对于浮游态菌还是生物被膜态菌，都能增强抗菌药物的杀菌或抑菌作用。其机制主要为空化效应。目前，低频超声技术已探索性应用于人体局部感染治疗中。作为一种可靶向治疗的非侵入性疗法，低频超声具有很大的临床应用潜能。此外，低频超声技术在基因转染上具有优势，并可通过改变基因来影响细菌耐药性。