粒细胞-巨噬细胞集落刺激因子联合放疗研究进展

摘要

粒细胞-巨噬细胞集落刺激因子(granulocyte-macrophage colony-stimulating factor,GM-CSF)作为一种造血因子可以有效诱导多种具有抑瘤效应的免疫细胞增殖,从而发挥抗肿瘤免疫反应.放疗作为肿瘤治疗的主要手段之一,不仅可以直接杀伤肿瘤细胞,而且会对抗肿瘤免疫产生影响.多项临床研究提示,放疗联合GM-CSF可以诱导产生旁观者效应并增强对肿瘤的远期控制,从而增强放疗的抗肿瘤效应.本文就GM-CSF及GM-CSF联合放疗的研究进展予以综述.%The granulocyte-macrophage colony-stimulating factor(GM-CSF)can effectively induce the proliferation of tumor-associat-ed immunocytes as a hematopoietic factor;therefore,the fact that GM-CSF can induce systemic antitumor immune responses has at-tracted much attention.Radiotherapy,as one of the main treatment approaches of cancer,can kill tumor cells directly,and has an ef-fect on anti-tumor immunity.Several clinical studies have shown that radiotherapy combined with the GM-CSF can induce an abscopal effect and confer favorable therapeutic effects for cancer.Herein,we review the research progress on GM-CSF,and radiotherapy com-bined with GM-CSF in tumor treatment.