Isolated antigen-binding protein, nucleic acid molecule, vector, host cell, methods for preparing antigen-binding protein, for treating or preventing a condition, for inhibiting granulocyte macrophage colony stimulating factor binding to the extracellular portion of granulocyte macrophage colony stimulating factor receptor, and to inhibit granulocyte macrophage colony stimulating factor activity, and, pharmaceutical composition

摘要

Antigen binding proteins that bind to human GM-CSF protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of GM-CSF to GM-CSFR, inhibit GM-CSF-induced proliferation and signaling of myeloid lineage cell lines and inhibit GM-CSF-induced activation of human monocytes.