珍菊降压片联合缬沙坦治疗原发性高血压（肝阳上亢证）患者的疗效观察

摘要

Objective:To study the efficacy of Zhenjujiangya tablet combined with angiotensin Ⅱ receptor blocker (ARB) val-sartan in the treatment of hypertension (upper hyperactivity of liver yang ) .Methods :A total of 60 patients with primary hyper-tension syndrome (upper hyperactivity of liver yang ) were randomly divided into treatment group (Zhenjujiangya tablet + val-sartan ,n=32) and control group (hydrochlorothiazide + valsartan ,n=28) .At 8 weeks after the treatment ,dynamic blood pressure ,blood pressure variability and TCM symptom score were observed .Results:After treatment ,compared with the con-trol group ,SBP ,d-SBP ,n-SBP in the treatment group were significantly lower (P<0 .05) ,whereas DBP ,d-DBP ,n-DBP had no significant difference (P<0 .05) .The blood pressure variability d-SBPV and n-SBPV in the treatment group were signifi-cantly lower than those in the control group (P<0 .01) ,but d-DBPV ,n-DBPV had no significant difference between the two groups (P>0 .05) .In the treatment group ,TCM symptoms(dizziness ,headache ,irritability) scores were significantly lower (P<0 .05) than those in the control group ,but limb symptoms integral differences had no difference between the two groups (P>0 .05) .Conclusions:Zhenjujiangya tablet in combination with valsartan therapy in patients with hypertension (upper hyperactivity of liver yang ) can not only effectively reduce the blood pressure and improve blood pressure variability ,but also improve the clinical symptoms of patients .%目的：观察珍菊降压片联合血管紧张素Ⅱ受体拮抗剂（angiotensin Ⅱ receptor blocker ，ARB）缬沙坦治疗高血压（肝阳上亢证）的疗效。方法：将原发性高血压（中医辨证为肝阳上亢证）患者60例随机分为治疗组（珍菊降压片＋缬沙坦）32例与对照组（双氢克脲噻＋缬沙坦）28例，经8周治疗后，观察两组治疗前后动态血压、血压变异性及中医症状评分的变化。结果：治疗后与对照组比较，治疗组平均收缩压（systolic blood pressure ，SBP）、白昼 SBP（daytime mean SBP ，d-SBP）、夜间 SBP （nighttime mean SBP ，n-SBP）均明显降低（P＜0．05），而两组平均舒张压（diastolic blood pressure ，DBP）、白昼DBP（daytime mean DBP ，d-DBP）、夜间DBP（nighttime mean DBP ，n-DBP）差异则无统计学意义（P＜0．05）；治疗组白昼SBP变异性（d-SB-PV）、夜间SBP变异性（n-SBPV）均明显降低（P＜0．01），而两组白昼DBP变异性（d-DBPV）、夜间DBP变异性（n-DBPV）差异则无统计学意义（P＞0．05）；治疗组中医症状（眩晕、头痛、易怒）评分均明显降低（P＜0．05），而两组肢体麻木症状积分差异则无统计学意义（P＞0．05）。结论：珍菊降压片联合缬沙坦治疗原发性高血压（肝阳上亢证）患者不仅可有效降低血压，改善血压变异性，还能改善患者的临床症状。