莫沙比利分散片在OMOM胶囊内镜检查中的应用研究

摘要

Objective To investigate the contribution of Mosapride dispersible tablet to the transporting time in gastrointestinal tract,the rate of complete small-bowel examination and the diagnostic yield. Methods 30 patients who received capsule endoscopy examination were divided into two groups randomly: test group ( n = 15 ) and control group ( n = 15 ). All the patients were absoluted diet after given fluid food for supper in the day before the examination. The patients of ihe two groups were received a bowel preparation 5 min before the examination. The test group were treated with mosapride dispersible tablet (5 mg) 15 min before the examination while the control group were not treated. Results The average gastric emptying time was 27 ?18 min in test group while 65 ?5 min in control group,and there were significant difference between the two groups (P<0.05). The average time of complete small- bowel examination was 240 ?45 min in test group while 290 ?60 min, in control group, and there were no difference between the two groups (P > 0.05). The rate of complete small-bowel examination was 93. 3% in test group while 3. 3% in control group, and there were significant difference between the two groups( P < 0. 05 ). The diagnostic yield of capsule endoscopy was 80% in tesl group while 66. 7% in control group,and there were significant difference between the two groups( P <0. 05 ). Conclusion It can reduce the gastric emptying time,raise the rate of complete small-bowel exami-nati on and the diagnostic yield of capsule endoscopy when oral administration mosapride dispersible tablet before capsule endoscopy examination. Mosapride dispersible tablet can be used before examination in the case of old patients or the patients who have insufficient gaster-power to raise the diagnostic yield of capsule endoscopy.%目的 探讨口服莫沙比利分散片对胶囊内镜检查中胃肠转运时间、全小肠检查完成率及胶囊内镜诊断率的影响.方法 将30例患者随机分为服药组(15例)和对照组(15例),所有患者检查前1天晚餐进流质后禁食.两组患者均在检查前5h行肠道准备.服药组检查前15 min口服莫沙比利分散片5 mg,对照组检查前不服用任何药物.结果 服药组平均胃排空时间为27±18 min,对照组为:65±25 min,两组比较差异有统计学意义(P＜0.05).完成全小肠检查者通过时间服药组平均为’240±45 min,对照组平均为290±60 min,两组比较差异无统计学意义(P＞0.05).全小肠检查完成率服药组为93.3％,对照组为73.3％,两组比较差异有统计学意义(P＜0.05).胶囊内镜诊断率服药组为80.0％,对照组为66.7％,两组差异有统计学意义(P＜0.05).结论 胶囊内镜检查前给予口服莫沙比利可以缩短胃排空时间,可能提高全小肠检查完成率和胶囊内镜诊断率.对年老体弱、胃动力不足的受检者,胶囊内镜检查前口服莫沙比利,可以提高胶囊内镜诊断率.