Objective:To study relationship between coronary heart disease (CHD) and dyslipidemia.Methods:A total of 302 CHD patients diagnosed by coronary angiography were enrolled as CHD group,and 218 healthy subjects without cardiovascular and cercbrovascular diseases by hearth examination were regard as healthy control group.Relative data were collected and levels of blood triglyceride (TG),total cholesterol (TC),high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were measured,and compared between two groups.Results:Compared with healthy control group,there were significant increase in levels of blood TC [(4.03±0.97) mmol/L vs.(4.62±1.06) mmol/L] and LDL-C [(2.51±0.86) mmol/L vs.(3.76±1.07) mmol/L] in CHD group,P＜0.01 both.Multiple factor Logistic regression analysis indicated that elevated LDL-C level was an independent risk factor for occurrence of CHD (OR =2.608,95％ CI =1.268-5.366,P=0.009).Conclasion:The results show that levels of TC and LDL-C in patients with coronary heart disease are significantly higher than those of healthy control group.Elevated LDL level may be an independent risk factor for occurrence of coronary heart disease.%目的:研究冠心病与血脂异常的相关性.方法:选择冠脉造影检查确诊的冠心病患者302例(CHD组),门诊体检无心脑血管疾病的健康人群218例(健康对照组),收集所有研究对象相关资料,测定其血甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白-胆固醇(LDL)、高密度脂蛋白-胆固醇(HDL-C)含量,并进行对比分析.结果:与健康对照组比较,CHD组血TC[(4.03±0.97) mmol/L比(4.62±1.06) mmol/L]、LDL-C[(2.51±0.86) mmol/L比(3.76±1.07) mmol/L]水平明显升高(P均＜0.01).多因素Logistic回归分析显示,LDL-C水平升高是冠心病发生的独立危险因素(OR=2.608,95％CI=1.268-5.366; P=0.009).结论:本研究人群冠心病患者TC、LDL-C水平显著高于健康对照组,LDL-C水平升高可能是发生冠心病的一个独立危险因素.
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