计算机体层摄影检查中对比剂肾病的流行病学研究

摘要

Objective To investigate the prevalence of contrast-induced nephropathy (CIN) in patients using intravenous contrast medium for CT examination, and to explore the risk factors relating to CIN. Methods Inpatients with CT examination in Peking University People's Hospital from January 2010 to June 2010 were studied retrospectively. We investigated the prevalence of CIN, and the risk factors for CIN were also characterized by using univariate and multifactor regression analyses. Results A total of 261 patients were involved in this study, of whom 7.7％ patients developed CIN. Comparing with non-CIN group, CIN group showed higher rates of hypotension and liver cirrhosis. Multifactor regression analysis demonstrated that hypotension was the independent risk factor for CIN. Conclusion CIN was not uncommon in inpatients using low osmolarity contrast medium for CT examination. Hypotension was recognized as the independent risk factor after controlling the factors of renal function and contrast medium dose.%目的 调查计算机体层摄影(computed tomography,CT)检查中对比剂肾病发生的情况,探讨相关危险因素.方法回顾性分析2010 年1 月至6 月在北京大学人民医院应用对比剂行CT 检查的住院患者资料,调查对比剂肾病的发生率,对比剂肾病发生的危险因素行单因素分析及多因素logistic回归分析.结果 261 例应用对比剂行CT 检查的患者中对比剂肾病发生率7.7%;与未发生对比剂肾病组比较,对比剂肾病组患者低血压、肝硬化的罹患率显著升高.二分类logistic 回归分析显示,低血压是对比剂肾病发生的独立危险因素.结论住院患者应用对比剂的CT 检查中,对比剂肾病的发生率7.7%,在规避了肾功能不全及造影剂剂量、种类等主要危险因素后,低血压是独立危险因素.