氯霉素-羟丙基-β-环糊精滴眼液抑菌实验研究

摘要

目的:比较氯霉素-羟丙基-β-环糊精滴眼液、氯霉素-玻璃酸钠滴眼液、氯霉素滴眼液对金黄色葡萄球菌、大肠埃希茵抑菌作用的差别.方法:对金黄色葡萄球菌、大肠埃希菌进行抑菌环实验.结果:三组不同处方氯霉素滴眼液对金黄色葡萄球菌和大肠埃希菌的抑菌作用无统计学差异.结论:羟丙基-β-环糊精增强了氯霉素滴眼液的稳定性而对其抑菌作用无明显影响.%Purpose To compare the bacteriostatic action of chloramphenicol-hydroxypropyl-β-cyclodextrin eye drops, chloramphenicol-sodium hyaluronate eye drops and chloramphenicol eye drops on Staphylococcus aureus and Escherichia coli. Methods The bacterial inhibition ring test was carried out for Staphylococcus aureus and Escherichia coli. Results There was no significant difference in bacteriostatic action of three different eye drops on Staphylococcus aureus and Escherichia coli. Conclusion Hydroxypropylβ-cyclodextrin enhances the stability of chloramphenicol eye drops, but has no effect on its bacteriostatic action.