泮托拉唑联合去甲肾上腺素注射液对消化性溃疡出血患者血清炎症因子及止血效果的影响

摘要

目的 探讨泮托拉唑与去甲肾上腺素注射液联合对消化性溃疡出血患者血清炎症因子水平及止血效果的影响.方法选取2014年9月~2016年9月浙江省奉化市人民医院收治的102例消化性溃疡出血患者根据随机分组法分为观察组(n=51)和对照组(n=51).观察组采用泮托拉唑与去甲肾上腺素注射液联合治疗,对照组仅采用泮托拉唑治疗.2组疗程均为3 d.对比分析2组治疗疗效,止血时间、住院时间及输血量,血清白细胞介素-6(IL-6)和IL-10水平变化,再出血发生率以及不良反应发生率.结果观察组总有效率(98.02%)显著高于对照组(82.35%)(P<0.05);观察组止血时间显著快于对照组(P<0.05),住院时间显著短于对照组(P<0.05),输血量显著少于对照组(P<0.05);2组血清IL-6、IL-10水平治疗后较治疗前减少(P<0.05);观察组血清IL-6、IL-10水平治疗后显著低于对照组(P<0.05);观察组再出血发生率显著低于对照组(P<0.05);治疗期间均未见明显不良反应.结论泮托拉唑与去甲肾上腺素注射液联合对消化性溃疡出血止血效果明显,可降低血清炎症因子水平,同时还可降低再出血发生率,安全可靠.%Objective To evaluate the effect of pantoprazole and norepinephrine injection on serum levels of inflammatory factors and hemostasis in the treatment of patients with peptic ulcer bleeding .Methods 102 cases of patients with peptic ulcer bleeding from September 2014 to September 2016 in our hospital were selected and randomly divided into observation group ( n =51 ) and control group ( n =51 ) .Observation group were received pantoprazole and norepinephrine injection combination therapy, the control group received only pantoprazole therapy.The treatment lasted 3 days.The efficacy, bleeding time, hospitalization and blood transfusion, serum IL-6 and IL-10 levels, the incidence of rebleeding and incidence of adverse reactions were compared between two groups.Results The overall response rate ( 98.02%) was significantly higher ( 82.35%) ( P<0.05 );observation group bleeding time was significantly faster than the control group ( P<0.05 ) , length of hospital stay was significantly shorter than the control group (P<0.05), blood transfusion was significantly less than the control group (P<0.05); levels of serum IL-6, IL-10 after treatment were lower than those before treatment (P<0.05); the serum levels of IL-6, IL-10 after treatment were significantly lower than those in control group (P<0.05); rebleeding rate in observation group was significantly lower than that in control group (P<0.05);there was no significant difference in adverse reactions between two groups.Conclusion Pantoprazole and norepinephrine injection in the treatment of digestive bleeding ulcer bleeding has the obvious effect, can reduce serum levels of inflammatory factors, while also reduce the incidence of rebleeding, safe and reliable.