ABHD11 is critical for embryonic stem cell self-renewal

摘要

Growing evidence supports the notion that lipid metabolism is critical for embryonic stem cell(ESC)maintenance.Recently,a/β-hydrolase domain-containing(ABHD)proteins have emerged as novel pivotal regulators in lipid synthesis or degradation while their functions in ESCs have not been investigated.In this study,we revealed the role of ABHD11 in ESC function using classical loss and gain of function experiments.K nockout of ABHD11 hampered ESC expansion and differentiation,triggering the autophagic flux and apoptosis.In contrast,ABHD11 overexpression exerted anti-apoptotic effects in ESCs.