非酒精性脂肪性肝病在2型糖尿病患者中的患病率及其危险因素研究

摘要

Objective To investigate the frequency and risk factors of non - alcoholic fatty liver disease ( NAFLD ) in patients with type 2 diabetes mellitus.Methods Blood samples of 312 patients were collected for assessment of glycemic and lip-id profiles, liver enzymes, and HOMA - IR.The diagnosis of NAFLD was established by ultrasound.Results NAFLD was diagnosed in 47.0％ of patients with higher waist circumference, body weight, and BMI ( P ＜ 0.01 ).The levels of triglycer-ides, insulin, and HOMA - IR were significantly higher in T2DM patients with NAFLD than those without NAFLD ( P ＜0.05 ).Conclusion lmost half of the patients with T2DM were found to have NAFLD.They showed elevated BMI, higher levels of tri-glycerides, insulin, and HOMA - IR compared with those without NAFLD.%目的 了解非酒精性脂肪性肝病(NAFLD)在2型糖尿病(T2DM)患者中的患病率,并分析其危险因素.方法 选取312例T2DM患者为研究对象,检测所有对象的肝肾功能、血糖、胰岛素、血脂等生化指标,并计算胰岛素抵抗指数(HOMA-IR).由超声诊断NAFLD.结果 T2DM患者中NAFLD患病率为47.0%(147/312).T2DM伴NAFLD组患者的腰围、体质量、体质指数(BMI)均显著高于单纯T2DM组,差异有统计学意义(P＜0.01).T2DM伴NAFLD组患者空腹胰岛素、三酰甘油水平、HOMA-IR、尿微量清蛋白(MALB)、合并代谢综合征的比例均显著高于单纯NAFLD组,差异有统计学意义(P＜0.05).结论 NAFLD在T2DM患者中患病率高,超重、腹型肥胖、高三酰甘油血症、高胰岛素血症是其发生的危险因素.