Objective To analyze the risk factors of diabetic foot in patients with type 2 diabetes mellitus ( T2DM ).Methods Clinical data and occurrences were analyzed retrospectively in 163 T2DM patients who were divided into groups diabetic foot ( DF, n = 63 ), non - diabetic foot ( NDF, n = 100 ). The risk factors of DF were analyzed by Logistic regression methocl. Results There was significant difference between 2 groups in BMI, fihrinogen ( FIB ), high density lipoprotein cholesterol ( HDI - C ), glycosylated hemoglobin Al ( HbA1c ), systolic blood pressure ( SBP ) levels and complications such as peripheral neuropathy, peripheral atherosclerosis ( P ＜ 0. 05 ) . Logistic regression analysis showed that FIB , SBP, arteriosclerosis obliterans and diabetic retinopathy were independent risk factors of DF in T2DM patients. Conclusion DF can he prevented by controlling blood glucose strictly and in a long term, by regulating the balance of blood pressure, lipid and FIB imbalance and by treating the chronic diabetic complications.%目的 探讨2型糖尿病患者糖尿病足发病的危险因素,尤其是独立的危险因素.方法 选取163例2型糖尿病患者,其中糖尿病足63例(DF组),非糖尿病足100例(NDF组),回顾性分析两组患者的临床资料及并发症发生情况,采用Logistic回归分析筛选糖尿病足的危险因素.结果 两组患者的体质指数(BMI)、纤维蛋白原(FIB)、高密度脂蛋白胆固醇(HDL-C)、糖化血红蛋白(HbA1c)、收缩压(SBP)水平以及并发症(周围神经病变、外周动脉粥样硬化闭塞症)发生率比较,差异均有统计学意义(P＜0.05).Logistic回归分析表明,FIB、SBP、外周动脉粥样硬化闭塞症和糖尿病视网膜病变是2型糖尿病发生糖尿病足的独立危险因素.结论 严格长期控制血糖及调节血压、血脂、FIB的失衡,积极治疗糖尿病各种慢性并发症,能预防糖尿病足的发生.
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